dr rollay dorsal column stimulator trial

#Dr rollay dorsal column stimulator trial how to
#Dr rollay dorsal column stimulator trial trial

“The ultimate goal of the trial is to improve peoples’ sense of well-being,” said Kreydin.

For patients with a spinal cord injury or a neurological disorder, the nerves controlling the bladder are either cut off or disrupted. Kreydin speculates that the stimulation retrains the spinal neural networks to properly store and void urine and to regain bladder sensation. The exact mechanism of how TESCoN improves bladder function is not known. In addition, trial participants will complete bladder symptom questionnaires before and after receiving the treatments to further track improvement. Researchers will then compare the data between the beginning and the conclusion of the trial, and between those receiving the real or sham stimulation.

The trial will track subjects’ number of daily urination and incontinence episodes over 72-hour periods. The other half of the participants will receive a placebo, or sham stimulation over course of the trial. The stimulation will be applied via electrodes attached to a device that emits low-intensity impulses through adhesive pads placed on the patient’s back. In this double-blinded, sham-controlled trial, half the participants will receive two one-hour sessions of TESCoN per week over 12 weeks. “TESCoN is well-tolerated by patients and easy for doctors to administer,” said Kreydin, who will be co-investigating the trial along with Keck Medicine urologist David Ginsberg, MD, a professor of clinical urology at the Keck School. Existing treatments for the condition can cause adverse side-effects or require invasive, highly specialized procedures. All patients reported improved bladder sensation as well as a reduced number of incontinence episodes and night-time bladder voiding.Īn overactive bladder causes several urological problems, such as frequent urination and incontinence. Kreydin and colleagues treated 14 patients with bladder dysfunction due to either spinal cord injury, stroke, multiple sclerosis or idiopathic cause with spinal cord stimulation sessions three times a week for eight weeks. The trial follows a recent study published in Frontiers in Systems Neuroscience led by Evgeniy Kreydin, MD, a Keck Medicine urologist and assistant professor of clinical urology at the Keck School of Medicine of USC. Researchers will use a technique known as Transcutaneous Electrical Spinal Cord Neuromodulation (TESCoN), a noninvasive therapy that delivers low-intensity electric impulses to the spinal cord. All clinical research activity is overseen and approved by the Research Executive Committee and reviewed by the Patient and Public Involvement (PPI) Panel to ensure research remains patient focused.Keck Medicine of USC urologists are launching a clinical trial to evaluate the effectiveness of spinal cord stimulation in patients with an overactive bladder due to neurological conditions - such as a spinal cord injury or stroke - and idiopathic (unknown) causes. The research team consists of the Clinical Research Lead (Dr Ram Hariharan, Spinal Cord Injury Consultant) and the Research Coordinator.

#Dr rollay dorsal column stimulator trial how to

Have previously participated or are currently participating in a research studyįor further information on the group and how to join email contact 01.įurther information for researchers, commercial partners and patients & the public on clinical research in the NHS can be found on the Clinical Research and Innovation Office (CRIO) webpage ( ).

A carer or relative of a patient requiring specialised rehabilitation.

Functional electrical stimulation services.

Amputee rehabilitation or prosthetic limb services.

Members can either attend the meetings in person or contribute via email.Īnyone with the following knowledge/experience is welcome to join the Group: The group meets three times a year and includes present and past users of the clinical services at the Centre. The Specialised Rehabilitation Lay Advisory panel exists to ensure that patients remain at the heart of all research designed and undertaken with the Centre. If you are interested in taking part in a research please speak with your clinical team in the first instance. By taking part in clinical research you will gain access to new research treatments often before they are widely available and of course you are giving hope to others by contributing to medical research. Through clinical trials, doctors find new ways to improve treatments and the quality of life for people living with spinal cord injuries.

Pressure ulcer prevention, treatment and managementĬlinical trials are research studies that involve people.

Over the past five years, we have been involved in a number of major studies funded by the National Institute for Health Research. We think it is really important to give our patients the opportunity to get involved in high quality research.